I too am lefty. Use a Browning A-Bolt 30-06. With 150 gr Hornaday Light magnums you will get out there in a hurry. Can't go wrong with a 30-06. If you want a flatter shooter a .270 is a nice round as well. But if you're only going to have one rifle, 30-06.
Sighted in at the range yesterday with 150-gr HLM an inch high at 100yds. Shot a half dozen rounds with 180-gr rounds that hit 8-inches lower. So FWIW make sure you sight in with what you're going to be hunting with.
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